![]() The currently fast-spreading Omicron variant contains many more mutations compared with the previous variants, and most of these mutations are located around the receptor binding domain of the spike protein.1 This would dramatically, although not completely, compromise the efficacy of the existing COVID-19 vaccines.2 Nearly all the monoclonal antibodies developed for treating COVID-19 are directed to the spike protein to prevent virus entry into human cells. Several variants of concern harboring multiple mutations in the spike protein have emerged in the past year. This is largely attributed to the viral polymerase that is intrinsically error prone and the selection pressures exerted by the host immune system. ![]() Since the first outbreak in late 2019, the RNA genome of SARS-CoV-2 has been undergoing constant evolution.
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